Toxic catatonia secondary to azithromycin.

Sir: Several publications report psychiatric symptoms induced by macrolide antibiotics. Clarithromycin and erythromycin used in combination with other treatments, or even in monotherapy, have been reported to produce acute psychoses, manic episodes, and depression. To our knowledge, this is the first report of an association between azithromycin, another macrolide antibiotic, and the initiation of acute psychotic depression with catatonic symptoms.